Breast cancer is a critical health issue affecting millions of women worldwide. October is Breast Cancer Awareness Month, dedicated to raising awareness, sharing experiences, and promoting research and prevention efforts.
For almost 40 years, more and more stakeholders have been working to make October the month of breast cancer awareness. This period is an opportunity to communicate, exchange, and share experiences about breast cancer among health professionals. It is essential to discuss early detection, treatments, and patient experiences to improve outcomes and support people globally.
Understanding the epidemiology of breast cancer is crucial for awareness, prevention and treatment efforts. With 2.3 million new cases diagnosed per year1, Breast cancer is the second most common type of cancer worldwide, after Lung, and first in Europe. Among women, breast cancer is the most common type of cancer, with 666K deaths each year worldwide1, however, thanks to early detection, improvement in treatments and treatment management, breast cancer mortality is reducing at a rate of 2-4% per year2.
Breast cancer is often categorized subtypes which are defined by the presence or absence of three receptors: oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Based on these factors, breast cancer is classified into four main molecular subtypes:
Identifying the molecular subtype of breast cancer is crucial because it helps doctors tailor the treatment plan. Targeted therapies are chosen based on the subtype to improve effectiveness and reduce unnecessary side effects.
APLUSA has been running studies on the different forms of Breast Cancer for the past 10 years, hence we have unique insights on the evolving management of this tumor type. To mark Breast Cancer awareness month this October we will provide insights and data on breast cancer, with feedback from doctors and patient experiences of Breast Cancer and summary data from:
Source: Social Media Listening, n=3.55M mentions. Scope: worldwide in English. Period: January-December 2023
We are observing a shift in the proportions of patients according to their HER2 status potentially due to:
Other factors contributing to the shifting on the proportions of patients according to their HER2 status can be related to:
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According to APLUSA’s recent HER2+ mBC Syndicated Tracker (Q2-2024), for second and third line therapies, patients predominantly receive mostly antibody-drug conjugates (ADCs) like trastuzumab deruxtecan or trastuzumab emtansine. In the third line, tyrosine kinase inhibitors (TKIs), primarily tucatinib, are also commonly administrated.
Clinical trials continue to explore novel approaches, and ongoing research aims to further understand the disease, identify new treatment targets, and improve survivorship and quality of life for patients.
Some HER2-targeted therapies for metastatic breast cancer (mBC) are currently under investigation:
According to APLUSA’s recent HER2+ mBC Syndicated Tracker (Q2-2024), the majority of patients with HER2+ metastatic Breast Cancer who are currently receiving their 2nd or 3rd line of treatment are over 65 years old, in good physical condition and have a moderate disease burden. Additionally, 25% of these patients also manage diabetes and nearly as many suffer from respiratory conditions such as COPD or moderate to severe asthma. Furthermore, 20% of the patients are smokers. The cancer has primarily metastasised mostly to the lungs, bones and liver.
Sources:
(2) https://www.who.int/news-room/fact-sheets/detail/breast-cancer